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Coreg is a non-selective blocker of beta-adrenoreceptors and selective bloacker of alpha-receptors. Nerves of the adrenergic system innervates the heart and release norepinephrine which stimulates the heart's muscle to beat more rapidly and forcefully.
Coreg reduces the heart's rate and force of contraction when it blocks such receptors and makes the work of the heart easier. Coreg blocks adrenergic receptors on arteries which relaxes them and causes blood pressure to fall. Coreg is taken twice daily with food since this increases the amount of absorbed drug.
Do not stop or change your dose without directions of your physician since it can result in serious cardiac complications (arrhythmias). Continue to take this medication even if you feel fine: probably you need to take blood pressure medications because your illness is life long.
Do not take this medication if you are allergic to Coreg, or if you have asthma, bronchitis, emphysema, severe liver disease, a serious heart condition (heart block, sick sinus syndrome, slow heart rate except cases with a pacemaker is used). Warn your surgeon if you are taking Coreg. Do not drink alcohol two our before or after your Coreg intake.
Decompensated heart failure, chronic obstructive lung disease, asthma, bronchitis, cardiogenic shock atrioventricular block (degree II and III), bradicardia, allergy to the components of Coreg, sick sinus syndrome and some other conditions.
Cautiousness should be exercised in patients with diabetes, low blood pressure, congestive heart failure, kidney disease, a thyroid disorder problems with circulation (such as Raynaud's syndrome).If you experience symptoms of allergy like hives, difficulty breathing, swelling of your face and also low or uneven heartbeats, feeling light-headed, fainting, feeling short of breath, even with mild exertion, swelling of your ankles or fee, nausea, clay-colored stool, jaundice, cold feeling in your hands and feet, contact your doctor and seek for immediate medical attention.
Due to the ability of Coreg to affect adrenergic system it may mask symptoms of hypoplycemia (tremors and increased heart rate) which are also stipulated by it.
Consequently sugar levels in patients with diabetes taking Coreg should be monitored more often. Irregular heart rhythm or an increase in blood pressure may appear when Coreg is used together with Ca+ channel blockers. Coreg may also increase levels of digoxin and while Rifampin decreases concentration of Coreg in blood.
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