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Udenafil is a therapeutic agent hypothesized to improve erectile function endpoints through interaction with the phosphodiesterase type 5 (PDE5) enzyme.
Udenafil has unique properties, with a T max of 1.0-1.5 h and a T 1/2 of 11-13 h (a relatively rapid onset and a long duration of action). Therefore, both on-demand and once-daily use of Udenafil have been reported.
Udenafil's efficacy and tolerability have been evaluated in several studies, and recent and continuing studies have demonstrated Udenafil's promise in both dosing regimens. Udenafil as an on-demand or once-daily dose is effective and tolerable, but more studies are needed in patients of other ethnicities and with comorbid conditions such as diabetes mellitus, hypertension, and benign prostate hyperplasia.
Sexual activity is a potential risk for patients with cardiovascular disease, so treatment of erectile dysfunction, including using of Udenafil, should not hold for men with heart disease, in which sexual activity is not recommended.
Patients with obstruction of blood outflow from the left ventricle (aortic stenosis) may be more sensitive to the action of vasodilators, including inhibitors of PDE. Despite the lack of clinical trials of cases of prolonged erection (longer than 4 hours) and priapism (painful erections lasting more than 6 h), such phenomena are peculiar to this class of drugs.
In the event of an erection lasting more than 4 hours (regardless of pain), patients should immediately seek medical help. In the absence of timely treatment of priapism can lead to irreversible damage to the erectile tissue and erectile function.
List of those who must take Zudena with extra caution: Patients with uncontrolled hypertension (blood pressure> 170/100 mm Hg.), hypotension (blood pressure <90/50 mmHg..); Patients with hereditary degenerative diseases of the retina (including retinitis pigmentosa, proliferative diabetic retinopathy); Patients who have undergone over the last 6 months of stroke, myocardial infarction or coronary artery bypass grafting; Patients with severe hepatic or renal impairment; presence of congenital long QT syndrome, or an increase in the QT interval as a result of taking the drugs; predisposition to priapism; patients with anatomical deformation of the penis; the presence of penile implant; sexual activity in patients with diseases of the cardiovascular system such as unstable angina or angina occurring during sexual intercourse, chronic heart failure (II-IV functional class NYHA classification), which developed during the last 6 months, uncontrolled heart rhythm disorders, - should take into account the potential risk of complications; while receiving of Udenafil and CCBs, alpha-blockers or other hypotensive drugs - may mark the additional reduction in SBP and DBP by 7-8 mmHg.
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