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Aciphex is an antiulcer medication which inhibits a proton pump (PPIs) and blocks the production of acid by the stomach. Biochemically it blocks the (H+,K+)-ATPase enzyme system hereby inhibiting the final stage of hydrochloric acid production. After peroral intake of Aciphex antisecretorial effect is reached during one hour and is maximal in 2-4 hours.
This medication is used to treat ulcers in stomach, Zollinger-Ellison syndrome, gastroesophageal reflux disease, to eradicate Helicobacter pylori in patients with ulcers in stomach or chronic gastritis.
Dosage should be administered by your doctor depending on your condition. Usually in patients with an acute duodenal ulcer and c it is recommended to take 1 tab (20 mg) in morning one time a day during 4-6 weeks.
When treating H. pylori infection, Aciphex may be needed for only a week. Follow all recommendations of your doctor and do not take this drug in larger amounts than it was prescribed to you. Tablets should be swallowed whole.
Do not crush, split or chew them. Take Aciphex with or without meals with a big glass of water since food has little effect on its absorption.Notify your doctor if you have a severe liver disease, cancer of stomach before to take this drug.
Use of Aciphex in children is not recommended. It is not expected to be harmful to an unborn baby, though inform your doctor if you are pregnant or breastfeeding.
Some conditions are treated with a combination of Aciphex and antibiotics, so to achieve maximal effect from treatment, use all of your medications as directed by your doctor.
Co-administration with the medications which absorption depends on acidity of the stomach causes interaction of medications. Aciphex and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin) causing reduction of effectiveness of the former and increase of toxicity of the latter.
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