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Zantac is a blocker of H2-histamine receptors. The mechanism of action consists in the blockade of histamine H2-receptors of parietal cells in gastric mucous layer.
This medication suppresses day and night secretion of HCl (both basal and stimulated), reduces the amount of gastric juices caused by stretching of the stomach with food load and by the action of hormones and biogenic stimulants such as gastrin, histamine, acetylcholine, pentagastrin, caffeine.
Zantac reduces the amount of HCl in gastric juice almost without suppressing "liver" enzymes associated with cytochrome P450. It does not affect the concentration of gastrin in plasma, production of mucus. Zantac reduces pepsin activity.
This medication is use to treat and prevent stomach and duodenal ulcers, gastrointestinal disorders caused by NSAID, heartburn, hypersecretion of gastric juice, symptomatic ulcers, ulcers caused by stress, erosive esophagitis, reflux esophagitis, Zollinger-Ellison syndrome and other conditions.
Take it orally with or without food. Correction of the dose should be made in patients with significantly abnormal liver or kidney function. Besides tablets this medication maybe administered intramuscularly (IM) or intravenously.
The Zantac effervescent tablet may contain phenylalanine. Notify your doctor if you are pregnant, plan to become pregnant or breastfeeding before to take Zantac.
Risk of developing pneumonia may be increased by this medication.
Hypersensitivity, breastfeeding. In patients with liver of kidney failure, cirrhosis of the liver, acute porphyria (also in history), children younger than 12 y.o., pregnancy this medication should be administered with cautiousness.
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