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Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.
Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose.
If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function.
Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome."
This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery. Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.
Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).
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