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Spiriva is a specific antagonist of muscarinic receptors with longterm action. It reversibly blocks receptors of M3 type in respiratory track which results in relaxation of smooth muscles of the bronchial tree.
High affinity of the receptors and slow release of the inhibitor from the complex with M3 receptor stipulates prolonged local action of Tiovais. Bronholitic effect of the drug results of local action, dose and persisted for at least 24 hours. Effects of Spiriva depend on the dose and continues for 24 hours.
The medication is used to treat bronchial spasms (wheezing) caused by chronic obstructive pulmonary disease, chronic bronchitis and emphysema.
Cautiousness is needed in treatment of patients with narrow-angle glaucoma, urination disorders caused by prostatic hypertrophy or obstruction of the bladder neck. Tiovais cannto be used for urgent blockage of a bronchial spasm.
Avoid getting of the medication in eyes. Monitoring on a regular basis is needed in the patients with moderate and severe renal failure treated by Tiovais and medications which excreted by the kidneys. Inhaled medications may cause paradoxical bronchospasm and other reactions of such kind.
Avoid administration of the medication if you are pregnant or breastfeeding.Most common side effects include local reactions such as dry mouth, throat pain, coughing, paradoxical bronchospasm.
Changes in accommodation if the medication got into the eyes. Allergic reactions (rash, swelling) are possible. In rare were observed cases short heart beat, acute glaucoma, difficulty urination in men with prostatic hypertrophy, constipation.
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