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The active ingredient present in Generic Sovaldi is Sofosbuvir – 400 mg.
Sofosbuvir is a nucleotide analog used in combination with other drugs for the treatment of hepatitis C virus (HCV) infection. Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone.
It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofosbuvir is also used in HCV patients with an HIV coinfection.
The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.
It is not known if sofosbuvir is safe and effective in children under 18 years of age.It is strongly recommended to consult your doctor or pharmacist before you start taking Generic Sovaldi and especially emphasize if you are allergic to this drug or if you take other medicines to treat Hepatitis C.
To make sure sofosbuvir is safe for you, tell your doctor if you have:
- liver problems other than hepatitis, or if you have had a liver transplant;
- kidney disease (or if you are on dialysis);
- HIV (human immunodeficiency virus);
- or if you have recently used a heart rhythm medicine called amiodarone (Cordarone, Pacerone).
Sofosbuvir is used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before using these medications together, and every month during your treatment.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using sofosbuvir with ribavirin.If you are a man, do not use this drug combination if your sexual partner is pregnant.It is not known whether sofosbuvir passes into breast milk or if it could harm a nursing baby.
You should not breast-feed while using this medicine.Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of these medicines: Amiodarone; Carbamazepine; Eliglustat; Fosphenytoin; Oxcarbazepine; Phenobarbital; Phenytoin; Primidone; Rifabutin; Rifampin; Rifapentine; St John's Wort; Tipranavir; Ulipristal.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Do not take more than 400 milligrams of sofosbuvir in one day.
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