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Sustiva is an antiviral medication to treat immunodeficiency syndrome (AIDS) or to prevent its development in the individuals who had sexual contacts with HIV-infected patients, injections and cuts while work with HIV-infected material. It belongs to the class of reverse transcriptase inhibitors and blocks synthesis of a viral DNA.The recommended dose for adults is 600 mg taken once daily.

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The daily dose for children with weight of 13-15 kg is 200 mg, for ones with 5-20 kg is 250 mg, for ones with 20-25 kg is 300 mg, for ones with 25?32,5 kg is 350 mg, for ones with 32,5?40 kg is 400 mg. Individuals with body weight over 40 kg should take 600 mg of Sustiva.

First two weeks take the medication before your bedtime. Inform your doctor if you have liver or kidney failure, alcohol or drug addicted, encephalopathy, high cholesterol or triglycerides, liver disease (including hepatitis B or C), if you have ever taken delavirdine (Rescriptor) or nevirapine (Viramune) without any therapeutic result. Cautiousness should be exercised in children under 3 years of age, and children with body weight under 13 kg.

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Use reliable contraception while you are on Sustiva as this medication may cause serious harm to an unborn baby.Sustiva decreases blood concentrations and effects of indinavir (Crixivan) and saquinavir (Invirase). Concomitant use with alcohol may increase influence of Sustiva on the central nervous system. Co-administration with Astemizol and tsizaprid increases risk of arrhythmia. Sustiva also decreases blood concentration of hormonal contraceptives and Indinavir.

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If Sustiva is used together with Ritonavir it leads to increase in side effects of the drug and hepatotoxicity. Concomitant use of Sustiva with Clarithromycin or Saquinavir should be avoided. Midazolam (Versed) and triazolam (Halcion) increase sedative effects of the drug. Phenobarbital decreases blood concentrations of Sustiva. Co-administration with rifabutin, rifampin is not recommended.

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