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Abilify is an add-on medication used for the treatment of major depressive disorder, schizophrenia, manic and mixed episodes associated with bipolar disorder in adults and children and adolescents and also of irritability associated with autistic disorder in pediatric patients. The mechanism of action of Abilify is unknown.
It shows partial agonism at the D2 receptor, it is also a partial agonist at the 5-HT1A receptor, and also displays an antagonist profile at the 5-HT2A receptor. It has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
This medication was not approved for use in elderly people with psychosis related to dementia-related psychosis due to the risk of death. Antidepressants increase suicidal thoughts or behaviors in some adolescents especially if the dose is changed or during first period of treatment.
Abilify was not approved for use in pediatric patients with depression. As Abilify is able impair judgment, thinking, or motor skills do not use is during operating hazardous machinery, including automobiles if you are not sure that Abilify therapy does not affect you adversely. Inform your doctor if you are pregnant, plan to become pregnant or breastfeeding before to take this medication. Avoid drinking any alcoholic beverages during treatment.
Avoid overheating and dehydration. Hyperglycemia, or elevated blood sugar, may occur when taking Abilify. If you have diabetes mellitus, monitor your blood sugar levels regularly.
Carbamazepine (Tegretol) decreases the levels of Abilifyole in the body stimulating the liver enzymes such as CYP3A4. Similar influence on Abilify is shown by phenytoin (Dilantin), rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate), and phenobarbital. Blocking of CYP3A4 by Ketoconazole (Nizoral) increases the amount of Abilify in the body.
Quinidine (Quinaglute, Quinidex) inhibits another liver enzyme known as CYP2D6 and also is able to increase the levels of Abilify. Other medicines with similar action are fluoxetine (Prozac) and paroxetine (Paxil). Abilify may dangerously increase blood sugar levels in patients with diabetes
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