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Motilium blocks pereferal and central dophamin receptors, removes inhibiting influence of dophamin on motor activity of gastrointestinal tract and increases evacuative and tone of stomach.
It has anti-vomiting effect, soothes hiccup and nausea.
Motilium is used to treat vomiting of different origin, hiccup, atonic gastrointestinal tract, necessity to accelerate peristalsis for X-ray examination, dispepsia caused by slow stomach, gastroesophageal reflux disease, esophagitis, gas, heartburn with or without passage of gastric contents into the mouth.
Take Motilium orally 30 minutes before a meal. In adults and children older than 5 y.o. take 10 mg 3-4 times a day when dispepsia is diagnosed. In patients with severe nausea and vomiting Motilium daily dose is 20 mg 3-4 times a day.
In patients with kidney failure correction of the dose is necessary, number of daily intakes should not exceed 1-2 times. This is only general recommendations and for each individual case consult your doctor as different conditions require different correction of the dose.
Hypersensitivity, bleeding in gastrointestinal tract, mechanical intestinal obstruction, perforation of the stomach or intestines, prolactinoma, infancy (younger than 5 y. o. and ones whose weight is less than 20 kg).
Caution should be experienced in patients with renal / hepatic insufficiency, during lactation, pregnancy.
Cimetidine and sodium bicarbonate reduce effects of Domperidone. Anticholinergic medications neutralize effect of Motilium. Blood levels of Motilium are increased by azole antifungal agents, macrolide antibiotics, HIV protease inhibitors, nefazodone (antidepressant). Motilium is compatible with antipsychotic (neuroleptics) medications, dopamine receptor agonists (bromocriptine, L-dopa).
Simultaneous treatment with paracetamol and digoxin had no effect on the concentration of these medications in the blood.
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