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Glipizide is sulfonylurea class of drugs a drug used to treat type 2 of diabetes and belongs to sulfonylurea class of drugs together with glimepiride (Amaryl), glyburide (Micronase, Diabeta), tolbutamide (Orinase) and tolazamide (Tolinase). It stimulates insulin secretion by beta-cells of pancreas.
Do not change your dose of Glipizide without first talking to your doctor. A starting dose when for immediate release tablets is 5 mg which should be taken 30 minutes before a meal.
The maximum dose is 40 mg daily. Maximum dose of extended release tablets should not exceed 20 mg daily. Take it with a full glass of water before a meal.
The best result of treatment is achieved when this medication is taken on a regular basis. Treatment with Glipizide may increase the risk of death from cardiovascular disease. Avoid drinking alcoholic beverages as it lowers blood sugar.
Do not chew, divide, or crush extended release tablets of Glipizide, swallow them whole.Hypersensitivity, insulin-dependent diabetes mellitus (juvenile diabetes, diabetes, accompanied by ketoacidosis or precoma) severe kidney or liver failure, stenosis of the gastrointestinal tract, infancy.
Alcohol delays effects of Glipizide by slowering its absorption. Glipizide should be administered 1-2 hours before cholestyramine as the latter affects its absorption. Fluconazole (Diflucan) increases absorption and effectiveness of Glipizide.
Medications which lower and rise blood sugar are able to change Glipizide effect: aspirin or another salicylate, nonsteroidal anti-inflammatory drugs, sulfa-based drugs such as sulfamethoxazole-trimethoprim (Bactrim, Septra), MAO- inhibitors, beta-blockers such as propranolol (Inderal), thiazide diuretics, steroid medicines such as prednisone (Deltasone, Orasone),estrogens, corticosteroids, thyroid medicines, phenothiazines such as chlorpromazine (Thorazine), niacin, phenytoin, and calcium channel blocking drugs.
Symptoms of Glipizide overdose are ones of low blood sugar: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma. If you experience one of them or any unusual symptoms call your doctor immediately.
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