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Valproic acid is used to treat convulsions, migraines and bipolar disorder. Exact mechanisms of its action are unknown. It is supposed that Valproic acid increases levels of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Valporic acid in very rare cases may cause life-threatening liver failure which are most prone to are children under two years old.
If children take more than one seizure medication they may be at more risk for liver problems. The risk also increases if they have a brain disease causing mental impairment (, multiple sclerosis, Creutzfeldt-Jacob disease, Huntington disease, a brain injury or infection). Valproic acid may also cause life-threatening pancreatitis which starts suddenly even when treatment with Valporic acid has been performed for several years.
If the following symptoms of early liver damage appear seek immediate medical help: stomach pain, nausea, vomiting, loss of appetite, dark urine, clay-colored stools, low fever, jaundice. Inform your doctor if you are pregnant or plan to become pregnant as this drug is able to cause birth defects. Presence of suicidal thoughts is possible during treatment with Valporic acid. If your mood or behavior change, you have depression, anxiety, hostile, hyperactive or have thoughts about hurting yourself and suicide notify your doctor.
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