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Oxcarbazepine is an antiepileptic drug used to treat seizure disorders (epilepsy). The exact mechanism of action of Oxcarbazepine and its active metabolite 10-monohydroxy metabolite (MHD) are unknown. Oxcarbazepine blocks potential-dependent sodium channels resulting in stabilization of overexcited neurons membranes, inhibition of a series of discharges in neurons and reduction of synaptic impulses.
Increased K+ conductance and modulation of Ca2+ channels activated by a high potential of the membrane also invest in the antiepileptic effect of the drug. Oxcarbazepine may rarely be used for treatment of bipolar disorder (manic-depressive disorder).
Oxcarbazepine is sold as a tablet and a suspension (liquid) to take orally. The medication is usually taken every 12 hours with or without food. Take Oxcarbazepine the same times every day to keep the level of medication in your blood constant.
Shake the suspension thoroughly before each use to make the mixture even. Do not suddenly stop taking this drug without your doctor's approval as seizures may become worse.Inform your doctor if you are allergic to oxcarbazepine, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), or any other medications and also inform about all drugs and herbal products you are taking.
Let him know if you have or have ever had kidney or liver disease, pregnant, plan to become pregnant, or are breast-feeding, using hormonal contraceptives. This medication can make you drowsy or dizzy, your mental health may change in unexpected ways and you may become suicidal.
If you experience severe symptoms listed below contact your doctor immediately: dizziness, drowsiness, vision changes, involuntary fast, repeating eye movements, diarrhea, constipation, heartburn, abdominal pain, loss of appetite, dry mouth, unstable gait, shaking of a part of the body that you cannot control, coordination disorders, slowed movements or thoughts, slow thinking and speech problems, difficulty concentrating, tooth and ear aches, sweating and hot flushes nose bleeding and signs of allergy such as swelling, redness, irritation, burning.
Call your doctor immediately if you have: swelling of the face, throat, tongue, lips, unusually long and frequent seizures, headache, nausea, vomiting, confusion, red or purple-colored blotches or dots on skin, jaundice, unusual bruising or bleeding, bleeding or tarry stools, joint pain, chest pain.
These medications are known to interact with Oxcarbazepine: amiodarone (Cordarone); amitriptyline (Elavil); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nimodipine (Nimotop), nisoldipine (Sular), nifedipine (Procardia), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpromazine (Thorazine);clomipramine (Anafranil); cyclophosphamide (Cytoxan, Neosar); desmopressin (DDAVP, Minirin, Stimate); diazepam (Valium); diuretics ('water pills'); hormonal contraceptives (birth control pills, rings, patches, implants, injections, and intrauterine devices); indapamide (Natrilix); other medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), phenobarbital, phenytoin (Dilantin), and valproic acid (Depakene, Depakote); proton-pump inhibitors such as lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix); theophylline (Theo-Dur); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluvoxamine (Luvox), escitalopram (Lexapro), paroxetine (Paxil), fluoxetine (Prozac, Sarafem), duloxetine (Cymbalta), and sertraline (Zoloft).
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