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Estrace belongs to the class of medications named estrogen replacement therapy.
Estrogen is a hormone produced by the ovaries, specific estrogen-receptors are located in different organs (in the uterus, vagina, urethra, mammary glands, liver, hypothalamus, pituitary) and stimulates development and growth of female sex organs starting from puberty: uterus, fallopian tubes, vagina, stroma and ducts of mammary glands, pigmentation of nipples and genitals, formation of secondary sexual characteristics of female type, formation of epiphyses of long bones.
Estrogen is responsible for the timely and regular rejection of the endometrium and bleeding, in high concentrations estrogen causes endometrial hyperplasia, suppress lactation, inhibits bone resorption. Estrace is used to treat menopause symptoms which include hot flashes, and vaginal dryness, burning, and irritation. It is also used for treatment of cancer treatment in women and men and osteoporosis.
Before to take Estrace inform your doctor if you have severe blood diseases, circulation problems, a hormone-related cancer (breast or uterine cancer), or excessive vaginal bleeding. Long-term treatment by Estrace may result in increased risk of breast cancer, heart attack, or stroke, cannot be used in pregnant women.
Hypersensitivity, pregnancy, estrogen depending malignant neoplasms, unusual or undiagnosed genital and uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancer).
Carefulness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (during takeing of estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder r disease in history, severe liver failure, jaundice, hepatic porphyria, hypercalcemia associated with metastases in bones caused by a breast cancer.
Only for treatment of breast and prostate cancer: diseases of the coronary or cerebral vessels, active thrombophlebitis or thromboembolic disease.Estrogen can inhibit the metabolism of cyclosporine resulting in increase of its levels in blood and kidney and/or liver damage.
Estrogen are abler to increase the risk of liver disease in patients treated by dantrolene. Known to affect a clot formation Estrace should be used carefully together with warfarin (Coumadin). Enhanced metabolism and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone.
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